CreXcel [ kree-EX-sell ] – noun: Mitochondrial creatine superfuel. Amplifies stored cellular energy capacity & maximizes ATP generation efficiency for unmatched gains in strength, power & muscle recovery.
Redefining Muscle Power!
- Saturates cellular creatine levels for optimal phospho-creatine ATP generation
- Fuels the Citric Acid Cycle with novel KrebsPower™ mineral cofactor substrate complex
- Supports mitochondrial efficiency with Water-Soluble Coenzyme Q10 (CoQ10) complex
- Boosts cellular Coenzyme Q10 levels over 100% with Q-Xcel™ Shilajit extract
- Increases muscular stamina & performance capacity with R2•Rev™ Rhodiola rosea extract
- Elevates muscle power, strength and recovery
CreXcel Ingredient Science
Creatine Monohydrate: Creatine monohydrate is critical to the energy replenishment cycle of muscle. Regular use of creatine can enhance power, endurance and energy levels while exercising allowing you to train harder longer and amplify results.
Magnesium: Magnesium is a co-factor in over 800 enzymatic reactions in our bodies. Deficiency of Mg can lead to decreased numbers of mitochondria per cell. Magnesium acts as a stabilizer of ATP, by binding to the phosphate groups. Deficiency in Mg, aside from having a negative impact on the energy production pathway required by mitochondria to generate ATP, also reduces the threshold antioxidant capacity of the aging organism and its resistance to free-radical damage. Mg also acts as an antioxidant against free radical damage of the mitochondria.
Calcium: Calcium is a key regulator of mitochondrial function and acts at several levels within the organelle to stimulate ATP synthesis. It is also highly involved in muscular tissue, playing a critical role in propagating action potentials, acetylcholine release and the start/stop of complex reactions leading to muscle contraction.
Niacin: Niacin or vitamin B3 is a key nutrient in cellular energy production. It is essentially responsible for 30 of the 38 potential ATP moles that can be made from one mole of glucose, via anaerobic and aerobic metabolism. A lack of niacin severely hampers any cell’s ability to generate energy to perform its unique function. Niacin shares with coenzyme Q10 the critical role of being a hydrogen mover in the mitochondrial energy equation, getting reduced to form NADH – a key cog in the electron transport chain responsible for ATP generation.
CoenzymeQ10: Coenzyme Q10 (CoQ10) plays an essential role in the electron transport chain within the mitochondria, facilitating the efficient transfer of electrons into ATP for use in cellular function. CoQ10 resides primarily on the inner membranes of the mitochondria; 95% of all cellular energy production depends on it. CoQ10 also acts as a powerful free radical scavenger, neutralizing their lethal action and dramatically reducing oxidative damage. The more available CoQ10 in the mitochondria, the less free radical damage occurs. This is one of the reasons why the highest CoQ10 concentrations are found in the most energy-intensive organs: the brain, heart, liver, and kidneys.
Exercise can boost longevity and even increase mitochondrial density in the short term; however, exercise can also damage the mitochondria in the long term. The high rate of oxygen and electron flow that exercise requires can lead to chronically low ATP levels, which may exert negative effects during vigorous exercise.
CoQ10 supplementation can counteract such effects, enhancing the adaptive response of skeletal muscle following exercise. CoQ10 supplementation before exercise increases muscle CoQ10 levels, reduces muscular oxidant stress, and may increase the amount of time you can exercise until exhaustion.
Several studies have found that CoQ10 supplementation (60 – 100mg/day for 4 – 8 weeks) improves aerobic power, anaerobic threshold, exercise performance and recovery after exercise in trained athletes and untrained individuals.
SHILAJIT: Shilajit is an ancient Ayurvedic medicine harvested in the Himalayas that acts as a powerful adaptogen. It is believed that shilajit’s two primary components, fulvic acid and dibenzo-a-pyrones (DBPs) are the active ingredients at work that can enhance mitochondrial energy flow. Fulvic acid independently stimulates mitochondrial energy metabolism, protects mitochondrial membranes from oxidative damage, and helps channel electron-rich DBPs into the mitochondria to support the electron transfer chain and ATP production. Fulvic acid works as an electron “shuttle,” augmenting CoQ10 to speed electron flow within mitochondria. The DBPs in shilajit serve as electron “reservoirs,” replenishing electrons lost by CoQ10 when it donates them to free radicals (thereby neutralizing them) and optimizing ATP generation efficiency.
As mentioned above strenuous exercise can induce ATP declines in muscle, blood and brain tissue. However supplementing with shilajit can dramatically reduce this natural decline by as much as 50%. Combining shilajit with CoQ10 supplementation can have an incredible synergistic effect, and has demonstrated increases in CoQ10 levels more than100% higher than supplementation of either ingredient alone.
Preliminary findings suggest that shilajit protects human tissue from lost energy in the form of ATP, while maximizing benefits from CoQ10, with dramatic improvement in exercise performance. Studies performed in mice on the ingredient combination produced a 56% increase in cellular energy production in the brain and 144% increase in muscle tissue.
RHODIOLA ROSEA: This Russian adaptogenic herb has been used for to boost energy and treat mental fatigue, along with other conditions. Rhodiola rosea relieves stress by balancing the body’s stress-response system. With constant stress, the system becomes unbalanced, making us feel edgy, tired, or depressed. Rhodiola rosea helps re-establish balance by strengthening the body’s response to physical, mental, and emotional stressors.
In addition to helping deal with mental stress, Rhodiola rosea extract has also been found very beneficial to combat the physical stresses of exercise. In a recent study, rhodiola-treated rats were able to swim for 25% longer before becoming exhausted, compared with animals that did not receive rhodiola. The researchers concluded that rhodiola enhances exercise capacity by activating the synthesis or re-synthesis of ATP and stimulating energy-repair processes after intense exercise.
These results carried over to human performance as well. Rhodiola supplementation helped improve exercise performance in healthy young adults who consumed rhodiola extract one hour before exercise significantly increased their capacity for endurance exercise. As well as liberating more energy for exercise, rhodiola also helps protect muscle tissue during exercise. This effect was seen in a study of healthy untrained volunteers after exhausting exercise, in whom rhodiola extract reduced levels of C-reactive protein, an inflammatory marker, and creatinine kinase, a marker of muscle damage.